Go 6976 کد ab141413 مقدار 500 µg ساخت کمپانی abcam
Go 6976 کد ab141413 مقدار 500 µg ساخت کمپانی abcam

 

اعتبار قیمت 95.7.1

 

لطفا پس از پایان اعتبار قیمت با تلفن 88920648 تماس حاصل فرمائید 

 

Overview

  • Product nameGo 6976
  • Description
    Potent PKC inhibitor. Selective for PKCα and PKCβ.
  • Biological descriptionPotent, selective PKC inhibitor (IC50 values are 2.3 and 6.2 nM at PKCα and β1, respectively). Selectively inhibits Ca2+-dependent PKC isoforms over Ca2+-independent. No inhibitory activity at PKCδ, ε or ζ. Antitumor agent. Active in vitroand in vivo.
  • Purity> 99%

Properties

  • Chemical name5,6,7,13-Tetrahydro-13-methyl-5-oxo-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-12-propanenitrile
  • Molecular weight378.43
  • Chemical structureChemical Structure
  • Molecula formulaC24H18N4O
  • CAS Number136194-77-9
  • PubChem identifier3501
  • Storage instructionsStore at -20°C. Store under Desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overviewSoluble in DMSO to 10 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILESCN1C2=CC=CC=C2C3=C4C(=C5C6=CC=CC=C6N(C5=C31)CCC#N)CNC4=O
  • Source

    Synthetic

  • Research areas

    References for Go 6976 (ab141413)

    This product has been referenced in:
    • Feng Z  et al. Chk1 inhibitor Gö6976 enhances the sensitivity of nasopharyngeal carcinoma cells to radiotherapy and chemotherapy in vitro and in vivo. Cancer Lett 297:190-7 (2010). Read more (PubMed: 20619533) »
    • Nikodemova M  et al. Minocycline down-regulates MHC II expression in microglia and macrophages through inhibition of IRF-1 and protein kinase C (PKC)alpha/betaII. J Biol Chem 282:15208-16 (2007). Read more (PubMed: 17395590) »
    • Martiny-Baron G  et al. Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976. J Biol Chem 268:9194-7 (1993). Read more (PubMed: 8486620) »

    فروشنده: آزمیران
    گارانتی اصالت و سلامت کالا
    پشتیبانی ۷ روز هفته ۲۴ ساعته
    ۱,۰۵۰,۰۰۰ تومان
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