Genipin (ab141049)

 Abcam  |  وارد کننده محصولات Abcam  | کیتهای Abcam  |  فروشنده محصولات Abcam  | شرکت Abcam

اعتبار قیمت 96.6.31

 

لطفا پس از پایان اعتبار قیمت درخواست خود را در سبد خرید قرار دهید در کمتر از 30 دقیقه قیمت جدید اعلام میگردد (سبد خرید زیر عکس میباشد)


Overview

  • Product nameGenipin
  • Description
    Cell-permeable uncoupling protein 2 inhibitor
  • Biological descriptionCell-permeable uncoupling protein 2 (UCP2) inhibitor. Anti-inflammatory, anti-angiogenic and pro-apototic effects. Acts as a protein cross-linker.
  • Purity> 99%

Properties

Applications

Our Abpromise guarantee covers the use of ab141049 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Functional Studies
Use at an assay dependent concentration.

Genipin images

  • ab28 staining p53 in HeLa cells treated with genipin (ab141049), by ICC/IF. Increase of p53 expression correlates with increased concentration of genipin, as described in literature.
    The cells were incubated at 37°C for 6h in media containing different concentrations of ab141049 (genipin) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab28 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-mouse polyclonal antibody (ab96879) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

References for Genipin (ab141049)

This product has been referenced in:
  • Parton LE  et al. Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity. Nature 449:228-32 (2007). Read more (PubMed: 17728716) »
  • Zhang CY  et al. Genipin inhibits UCP2-mediated proton leak and acutely reverses obesity- and high glucose-induced beta cell dysfunction in isolated pancreatic islets. Cell Metab 3:417-27 (2006). Read more (PubMed: 16753577) »
  • Kim BC  et al. Genipin-induced apoptosis in hepatoma cells is mediated by reactive oxygen species/c-Jun NH2-terminal kinase-dependent activation of mitochondrial pathway. Biochem Pharmacol 70:1398-407 (2005). Read more (PubMed: 16143311) »


فروشنده: واردکننده
گارانتی اصالت و سلامت کالا
پشتیبانی ۷ روز هفته ۲۴ ساعته
۱,۶۵۰,۰۰۰ تومان
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فروش مواد شیمیایی فقط جهت مراکز دولتی، شرکتها، پژوهشگاهها، محققین و اساتید دانشگاه انجام میشود لطفا درخواست خود را به شماره واتس آپ یا تلگرام یا ایتا 09365036989 ارسال کنید